(produces in vivo nerve growth factor)

Xanthohumol, is a  prenylated chalcone, also a prenylflavonoid, and falls within the range of compounds called Xanthones (one of the primary compounds in St. Johns Wort).  Xanthohumol was initially detected in an extract(series of Humulones) from Hops (Humulus lupulus), and is present in beer, although one would have to drink 120 gallons of beer per day to have any significant biological effect. Only comparatively minute quantities of xanthohumol are available in hops. The different flavonoid compounds in hops have been shown to have many medical benefits.  Xanthohumol didn't have a real, practical, safe source until the discovery of the Ashataba plant.

	Influence of prenylated and non-prenylated flavonoids on liver microsomal lipid peroxidation and oxidative injury in rat hepatocytes ;Food Chem Toxicol. 2001 May;39(5):437-45. Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4, 5-f]quinoline, mediated by cDNA-expressed human CYP1A2. Drug Metab Dispos. 2000 Nov;28(11):1297-302. Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro. J Agric Food Chem. 2000 Sep;48(9):3876-84. Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells. Cancer Lett. 2000 Feb 28;149(1-2):21-9. Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry. 1997 Oct;46(4):683-7. Xanthohumol from hop extract for osteoporosis and to inhibit bone resorption; US Patent 5,679,716 Humulones for osteoporosis; US Patent 5,604,263	Antioxidant Flavonoids (listed in order of decreasing potency) Quercetin (a flavonol in vegetables, fruit skins, onions). Xanthohumol (a prenylated chalcone previously found only in hops and beer) Isoxanthohumol (a prenylated flavanone in hops and beer)  Genistein (an isoflavone in soy) Pro-oxidant flavonoids  Chalconaringenin (a non-prenylated chalcone in citrus fruits)  Naringenin (a non-prenylated flavanone in citrus fruits) External Link: Antioxidant Activities of Flavonoids
		Factoid: In vitro tests have shown that it takes only 100 µM of prenylflavonoids to achieve an anti proliferating and cytotoxic effect in a culture of 500,000 tumor cells. The in vitro laboratory tests showed no toxicity. Prenylflavonoids  have anti-allergic, anti-inflammatory, anti-viral, anti-fungal, anti-bacterial, anti-oxidizing properties. C.L.. Miranda et al: In Food and chemical Toxicology 37 (1999) 273 - 285; J.F. Stevens et al:In J Am. Soc. Brew. Chem. 56(4) 136 - 145, 1998 ; A Alt et al: Deutsches Krebsforschungszentrum. Abt. C0202, D-69129 Heidelberg.